Wachiraporn Wongvaree. Left ventricular volumes and ejection fraction calculated from 99mTc-MIBI myocardial perfusion gated spect : effect of filtering and zooming in comparison with gated blood pool . Master's Degree(Radiological Science). Mahidol University. : Mahidol University, 2004.
Left ventricular volumes and ejection fraction calculated from 99mTc-MIBI myocardial perfusion gated spect : effect of filtering and zooming in comparison with gated blood pool
Abstract:
The calculation of left ventricular ejection fraction (LVEF) relies upon the identification of the endocardial surface, which will be affected by the spatial resolution and statistical noise in the reconstructed images. The aim of this study was to test different reconstruction filters and reconstruction zooms, parameters to reconstruct different images of the heart at rest using 99mTc-MIBI myocardial perfusion gated SPECT (GSPECT) method. This test was performed in 26 patients. End-diastolic volume (EDV), end-systolic volume (ESV) and left ventricular ejection fraction (LVEF) were calculated using the Cedar-Sinai QGS package. EDV, ESV and LVEF were calculated in all patients using Gated blood pool (GBP). The result showed, that GSPECT with Butterworth filter = 5.40 and zoom factor = 2.5 simultaneously offers mean LVEF value (55% _ 2.32%) similar to GBP (55.87% _ 10.8%), optimal correlations with GBP (r = 0.708) and minimal mean difference with GBP (M _ SD = -0.87% _ 8.86%). Correlation coefficients between GSPECT LVEF and GBP LVEF ranged from 0.668 to 0.725. Correlation coefficients between GSPECT volumes and GBP volumes ranged from 0.488 to 0.812. There was a significant effect of filtering and zooming on EDV, ESV and LVEF (p<0.05). Low cutoff frequency overestimated EDV, ESV and underestimated LVEF measurements. Small reconstruction zooms underestimated EDV and ESV compared with large reconstruction zooms. Therefore, according to this study LVEF is overestimated. In conclusion, accurate LVEF measurement can be obtained from 99mTc-MIBI myocardial perfusion gated SPECT. However, filtering and zooming greatly influence
EDV, ESV and LVEF measurements.