Chemical constituents and its biological activities from derris malaccensis

Name: Vorawan Kongjinda

LCSH: Kasetsart University -- Theses. M.S. (Chemistry) 2004

LCSH: Leguminosae

LCSH: Derris

LCSH: Plant bioactive compounds

Classification :.LCCS: QK495.L52

Abstract: The air-dried leaves of D. malaccensis were extracted with hexane, ethyl acetate and methanol, respectively. The ethyl acetate extract was fractionated by the use of chromatographic techniques. Two new prenylated chalcones, 2',4'-dihydroxy-4-methoxy-3'-prenylchalcone (c) and 2',4'-dihydroxy-4-methoxy-3'(2"-hydroxy-3"-methyl-3"-butenyl) chalcone (d), together with the known beta-sitosterol (b) and oblongifolic acid (a) were isolated. Their structures were elucidated by the use of 2D NMR spectroscopic methods. The structure of compound c was further confirmed by a combination of chemical transformations and X-ray crystallography. Compound c showed moderate to good activities against Staphylococus aureus, Erwinia stewartii, Bacillta cereus,Escherichia coli and Salmonella groups. Compounds c and d exhibited cytotoxic activity against human small cell lung cancer (NC1-H187) with IC50 9.1 and 9.9 micro g/ml, respectively.

Kasetsart University. Office of the University Library

Address: กรุงเทพมหานคร (Bangkok)

Email: tdckulib@ku.ac.th

Name: Supanna Techasakul

Role: Thesis Advisor

Created: 2004

Issued: 2006-11-06

Modified: 2006-11-06

วิทยานิพนธ์/Thesis

URL: http://www.lib.ku.ac.th/KUthesis/VorawanKon/index.html

ISBN: 974-273-169-1

CallNumber: QK495.L52 .V67

eng

DegreeName: Master of Science

Level: Master's Degree

Descipline: Organic Chemistry

Grantor: Kasetsart University

©copyrights Kasetsart University

ลำดับที่.	ชื่อแฟ้มข้อมูล	ขนาดแฟ้มข้อมูล	จำนวนเข้าถึง	วัน-เวลาเข้าถึงล่าสุด
1	cert.pdf	346.02 KB	7	2018-05-15 04:46:35
2	tp.pdf	53.7 KB	8	2018-05-15 04:46:36
3	abst.pdf	346.86 KB	10	2018-05-15 04:46:36
4	ack.pdf	52.18 KB	7	2018-05-15 04:46:37
5	toc.pdf	106.83 KB	6	2018-05-15 04:46:38
6	chapter1.pdf	307.16 KB	9	2018-05-15 04:46:39
7	chapter2.pdf	517.67 KB	10	2018-05-15 04:46:39
8	chapter3.pdf	113.17 KB	12	2024-11-09 19:57:13
9	chapter4.pdf	339.23 KB	9	2018-05-15 04:46:40
10	chapter5.pdf	74.76 KB	9	2018-05-15 04:46:41
11	ref.pdf	93.32 KB	6	2018-05-15 04:46:42
12	appdx.pdf	393.91 KB	7	2018-05-15 04:46:43

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